Boosting dark matter searches at muon colliders with Machine Learning: the mono-Higgs channel as a case study

The search for dark-matter (DM) candidates at high-energy colliders is one of the most promising avenues to understand the nature of this elusive component of the universe. Several searches at the Large Hadron Collider (LHC) have strongly constrained a wide range of simplified models. The combination of the bounds from the LHC with direct-detection experiments exclude the most minimal scalar singlet DM model. To address this, Lepton portal DM models are suitable candidates where DM is predominantly produced at lepton colliders since the DM candidate only interacts with the lepton sector through a mediator that carries a lepton number. In this work, we analyse the production of DM pairs in association with a Higgs boson decaying into two bottom quarks at future muon colliders in the framework of the minimal lepton portal DM model. It is found that the usual cut-based analysis methods fail to probe heavy DM masses for both the resolved (where the decay products of the Higgs boson can be resolved as two well-separated small-$R$ jets) and the merged (where the Higgs boson is clustered as one large-$R$ jet). We have then built a search strategy based on Boosted-Decision Trees (BDTs). We have optimised the hyperparameters of the BDT model to both have a high signal-to-background ratio and to avoid overtraining effects. We have found very important enhancements of the signal significance with respect to the cut-based analysis by factors of $8$--$50$ depending on the regime (resolved or merged) and the benchmark points. Using this BDT model on a one-dimensional parameter space scan we found that future muon colliders with $\sqrt{s}=3$ TeV and ${\cal L} = 1~{\rm ab}^{-1}$ can exclude DM masses up to $1$ TeV at the $95\%$ CL.Comment: 22 pages, 9 figures, and 11 table

Unfavorable apoAI-containing lipoproteins profile in Tunisian obese women group

ApoAI-containing lipoproteins, which have been reported in relation with the development of ischemic diseases, have never been studied in obese subjects that have any other factor affecting the lipoproteins metabolism. Control and obese women groups were constituted on the basis of the body weight: less than 110% and more than 125% of the ideal body weight, respectively. Different lipid and lipoprotein parameters, including the two apoAI-containing lipoproteins species, were quantified. Compared to control group, obese group exhibited a higher levels of plasma triglycerides, high density lipoprotein-triglycerides (HDL-TG) and lipoproteins with both apo AI and apo AII (LpAI:AII) but a lower values of plasma-apoAI percentage associated with LpAI particles (P < 0.05). The other studied parameters, including the distribution of apoAI and LpAI between HDL and non-HDL fractions, were similar in the two subject groups. In our obese subjects, plasma TG appear to be the more determinant for the atherosclerosis risk as suggested by their strong positive and negative correlation with LpAI:AII (P < 0.001) and with LpAI/LpAI:AII, respectively. The profile of apoAI-containing lipoproteins appears to be more sensitive to obesity effect than traditional lipid and lipoprotein parameters. The nature of its alteration could explain, at least in part, the association of obesity with high atherosclerosis risk.Key words: Obesity, atherosclerosis, apoAI-containing lipoproteins

Change of Diet, Plasma Lipids, Lipoproteins, and Fatty Acids during Ramadan: A Controversial Association of the Considered Ramadan Model with Atherosclerosis Risk

Different Islamic populations have different alimentary habits, notably during Ramadan. The paper reports the change of diet, lipids, and lipoproteins produced during Ramadan in one Tunisian population. During Ramadan, the study subjects consumed more proteins, cholesterol, vitamin E (p<0.01), and polyunsaturated fatty acids (p<0.05). At the same time, they exhibited an increase in total cholesterol, low-density lipoprotein-cholesterol (p<0.01) and apoprotein B (p<0.05) and a decrease in the ratio of apoprotein AI to apoprotein B (p<0.01). All assayed saturated fatty acids were unaffected by Ramadan fasting while three unsaturated fatty acids (C18:1cis9, C18:2n-6, and C30:4n-6) increased significantly. A return to the habitual diet for a four-week period was not sufficient to restore the pre-fasting patterns. For the study subjects, Ramadan was clearly associated with a change of diet and biochemical profile but its effective impact on atherosclerosis risk was unclear, perhaps, because other non-alimentary changes ought to be considered too. Future studies considering the non-alimentary factors, such as sleep and physical activity, would be useful to clarify the contribution of dietary change in the observed modification of biological profile

(Cryptand-222)potassium(+) (hydrogensulfido)[5,10,15,20-tetra­kis(2-pival­amido­phen­yl)porphyrinato]ferrate(II)

As part of a systematic investigation for a number of FeII porphyrin complexes used as biomimetic models for cytochrome P450, crystals of the title compound, [K(C18H36N2O6)][FeII(C64H64N8O4)(HS)], were prepared. The compound exhibits a non-planar conformation with major ruffling and saddling distortions. The average equatorial iron–pyrrole N atom [Fe—Np = 2.102 (2) Å] bond length and the distance between the FeII atom and the 24-atom core of the porphyrin ring (Fe—PC= 0.558 Å) are typical for high-spin iron(II) penta­coordinate porphyrinates. One of the tert-butyl groups in the structure is disordered over two sets with occupancies of 0.84 and 0.16

Dichlorido(5,10,15,20-tetra­phenyl­porphyrinato-κ4 N)anti­mony(V) hemi{di-μ-chlorido-bis­[trichloridoanti­monate(III)]} dichloro­methane monosolvate

The asymmetric unit of the title complex, [Sb(C44H28N4)Cl2][Sb2Cl8]0.5·CH2Cl2, is composed of a SbV complex cation wherein the Sb atom is hexa­coordinated by four N atoms of the pyrrole rings of the tetra­phenyl­porphyrinate (TPP) ligands and two chloride ions, a half di-μ-chlorido-bis­[trichloridoanti­monate(III)] counter-anion and a dichloro­methane solvent mol­ecule. In the cation, the average Sb—N distance is 2.066 (2) Å, while the Sb—Cl distances are 2.3410 (11) and 2.3639 (12) Å. The central unit of the cation, SbN4C20, is far from being planar, with deviations of atoms from the least-squares plane ranging from −0.110 (4) to 0.124 (4) Å. The Sb—Cl distances in the anion, which is located about an inversion center, lie in the wide range 2.3715 (13)–2.7489 (13) Å, the longest distances being between the Sb and bridging Cl atoms. The crystal structure is stabilized by inter­molecular C—H⋯Cl inter­actions involving the cations, the anions and the solvent mol­ecules. The solvent mol­ecule is disordered over two orientations in a 0.901 (13):0.099 (13) ratio

A peptidomic approach for the identification of antioxidant and ACE-inhibitory peptides in sardinelle protein hydrolysates fermented by Bacillus subtilis A26 and Bacillus amyloliquefaciens An6

Antioxidant and angiotensin I-converting enzyme (ACE)-inhibitory activities of sardinelle (Sardinella aurita) protein hydrolysates (SPHs) obtained by fermentation with Bacillus subtilis A26 (SPH-A26) and Bacillus amyloliquefaciens An6 (SPH-An6) were investigated. Both hydrolysates showed dose-dependent antioxidant activities evaluated using various in vitro antioxidant assays. Further, they were found to exhibit ACE-inhibitory activity. Peptides from SPH-A26 and SPH-An6 were analyzed by nESI-LC–MS/MS and approximately 800 peptides were identified. Identified peptides derived mainly from myosin (43% and 31% in SPH-An6 and SPH-A26, respectively). Several peptides identified in both hydrolysates were found to share sequences with previously identified antioxidant and ACE-inhibitory peptides based on Biopep database. Some of these peptides were selected for synthesis and their biological activities were evaluated. Among the synthesized peptides, NVPVYEGY and ITALAPSTM were found to be the most effective ACE-inhibitors with IC50 values of 0.21 and 0.23 mM, respectively. On the other hand, NVPVYEGY, which exhibited the highest ACE-inhibitory activity, showed the highest reducing power and peroxyl radical scavenging activities, followed by SLEAQAEKY and GTEDELDKY. The results of this study suggest that fermented sardinelle protein hydrolysates are a good source of natural antioxidant peptides and could have the potential to act as hypotensive nutraceutical ingredients.This work was funded by grant AGL2014-57367-R from MINECO and FEDER funds as well as the Ministry of Higher Education and Scientific Research-Tunisia and the Emerging Research Group Grant from Generalitat Valenciana in Spain (GV/2015/138). JAEDOC-CSIC postdoctoral contract of L.M. cofunded by the European Social Found is also acknowledged. LC-MS/MS analysis was carried out in the SCSIE University of Valencia Proteomics Unit (Spain), a member of ISCIII ProteoRed Proteomics Platform.Peer reviewe

Общие аспекты состояния фауны птиц Крыма. Сообщение 2. Ретроспективный анализ состава авифауны и характера пребывания птиц Равнинного Крыма

У роботі наведено результати ретроспективного аналізу складу авіфауни рівнинної частині півострову, а також змін фенологічного статусу видів за останні 150 років.The present work demonstrates results of retrospective analysis of avifauna composition for the plain part of the peninsula and changes in species phenological studies over the past 150 years

Construction of an ontology for intelligent Arabic QA systems leveraging the Conceptual Graphs representation

The last decade had known a great interest in Arabic Natural Language Processing (NLP) applications. This interest is due to the prominent importance of this 6th most wide-spread language in the world with more than 350 million native speakers. Currently, some basic Arabic language challenges related to the high inflection and derivation, Part-of-Speech (PoS) tagging, and diacritical ambiguity of Arabic text are practically tamed to a great extent. However, the development of high level and intelligent applications such as Question Answering (QA) systems is still obstructed by the lacks in terms of ontologies and other semantic resources. In this paper, we present the construction of a new Arabic ontology leveraging the contents of Arabic WordNet (AWN) and Arabic VerbNet (AVN). This new resource presents the advantage to combine the high lexical coverage and semantic relations between words existing in AWN together with the formal representation of syntactic and semantic frames corresponding to verbs in AVN. The Conceptual Graphs representation was adopted in the framework of a multi-layer platform dedicated to the development of intelligent and multi-agents systems. The built ontology is used to represent key concepts in questions and documents for further semantic comparison. Experiments conducted in the context of the QA task show a promising coverage with respect to the processed questions and passages. The obtained results also highlight an improvement in the performance of Arabic QA regarding the c@1 measure.The work of the last author was carried out in the framework of the WIQ-EI IRSES project (Grant No. 269180) within the FP 7 Marie Curie, the DIANA APPLICATIONS - Finding Hidden Knowledge in Texts: Applications (TIN2012-38603-C02-01) project, and the VLC/CAMPUS Microcluster on Multimodal Interaction in Intelligent Systems.Abouenour, L.; Nasri, M.; Bouzoubaa, K.; Kabbaj, A.; Rosso, P. (2014). Construction of an ontology for intelligent Arabic QA systems leveraging the Conceptual Graphs representation. Journal of Intelligent and Fuzzy Systems. 27(6):2869-2881. https://doi.org/10.3233/IFS-141248S2869288127

Study of Heat Dissipation Mechanism in Nanoscale MOSFETs Using BDE Model

In this chapter, we report the nano-heat transport in metal-oxide-semiconductor field effect transistor (MOSFET). We propose a ballistic-diffusive model (BDE) to inquire the thermal stability of nanoscale MOSFET’s. To study the mechanism of scattering in the interface oxide-semiconductor, we have included the specularity parameter defined as the probability of reflection at boundary. In addition, we have studied the effective thermal conductivity (ETC) in nanofilms we found that ETC depend with the size of nanomaterial. The finite element method (FEM) is used to resolve the results for a 10 nm channel length. The results prove that our proposed model is close to those results obtained by the Boltzmann transport equation (BTE)